Skip to main content
OpenTrials
Completed

NCT Number: NCT03872284

Neuro-ophthalmology and Autoimmune Encephalitis (NODE)

Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described. Cerebral areas and neuronal networks associated with these abnormalities are well described. The investigator proposes to study and describe such neuro-ophthalmological disorders in a prospective cohort of patients with a autoimmune encephalitis, to better understand the pathophysiological basis of this neurological condition.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Autoimmune Encephalitis Autoimmune Diseases Autoimmune Diseases of the Nervous System Immune System Diseases Nervous System Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civils de Lyon

Bron, 69500, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of autoimmune encephalitis
  • With or without pathological antibody
  • Aged from 18 to 70 years old
  • Able to understand the aims and methods of this project
  • Non opposed to the participation of this study

Exclusion criteria

  • Other neurological, psychiatric or systemic conditions, which could induce neuro-ophthalmological signs Cognitive impairment, which is not linked to autoimmune encephalitis
  • Ophthalmological condition, which could modify the interpretation of neuro-ophthalmological data Inability to remain seated
  • Pregnancy or breast feeding
  • Adults under guardianship

Treatment and study plan

oculomotor movement recordings, neurovisual assessment

Other

Each participant will have a neurovisual assessment and an oculomotor movement recording with an eye tracker (infra red cameras).

Primary outcomes

  1. Percentage of patients presenting a neuro-ophthalmological abnormality.

    Time frame: Day 0

    A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.

  2. Percentage of patients presenting neuro-ophthalmological abnormality.

    Time frame: At 6 months if an abnormality is found

    A neuro-ophthalmological disorder is defined as an abnormality in the oculo-motor movement recording or/and the presence of a neurovisual impairment.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Study of Neuro-ophthalmology Disorders in Autoimmune Encephalitis (NODE)

Acronym: NODE

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Mar 13, 2019
Registry last updated
Jan 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.