Pedicatric Obesity - Weight - Energy - Loss - Load
NCT06085040
Body Weight, Nutrition Disorders
Clermont-Ferrand, France
View Trial DetailsNCT Number: NCT02759523
Increased portion sizes of foods high in energy density (calories per gram of food) have been implicated in the obesity epidemic. Numerous studies show that children and adults eat more from larger portions of food than they do from smaller portions, a response known as the portion size effect. Despite the robust and consistent nature of these findings, the mechanisms underlying the portion size effect are not known. The long-term goal of this research is to identify the neural mechanisms involved in the portion size effect so that this information can be used to develop effective weight-management strategies. Differences in neural response to food cues, as demonstrated by functional magnetic resonance imaging (fMRI), can help clarify the factors that determine susceptibility to large portions. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.
The investigators hypothesize that high relative to low energy density food images will be associated with increased activation in regions of the brain involved in reward- and sensory- processing and that large relative to small portion size food images will be associated with increased activation in regions of the brain involved in cognitive control. In addition, the investigators hypothesize that these brain responses will influence the relationship between portion size served and energy intake at laboratory meals.
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Notify Me7 year–10 year
All sexes
Observational
What this study will add to the literature: The response to food images that vary by portion size using fMRI has not been previously reported. Furthermore, how the brain response to food portion size and energy density is related to energy intake has not been previously reported. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Collected at fMRI scan (1 of 1) at week 5
Whole-brain response to food images that varied at 2 levels of portion size and 2 levels of energy density
Time frame: Collected at week 1, 2, 3, and 4
Energy intake (kcal and grams) of foods consumed ad libitum at each laboratory test-meal in response to 4 conditions of portion sizes (100% reference, 133%, 167%, 200%).
Time frame: Collected at fMRI scan (1 of 1) at week 5
Response in selected brain regions of interest to food images varied at 2 levels of portion size and 2 levels of energy density
Time frame: Collected at week 1 (Baseline)
Parent-reported questionnaire of habitual eating styles in children
Time frame: Collected at week 1 (Baseline)
Height, weight and body fat percentage were measured. Body mass index (BMI), BMI z score, fat-mass index and fat-free-mass index will be calculated.
Time frame: Collected at week 5
Ratings of how much child likes food presented on a computerized visual analog scale
Time frame: Collected at week 5
Ratings of how much child wants food presented on a computerized visual analog scale
Time frame: Collected at week 1 (Baseline)
Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.
Time frame: Collected at week 1 (Baseline)
Parent-reported measures of feeding practices
Penn State University
Other
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