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OpenTrials
Completed

NCT Number: NCT02759523

Neural Mechanisms Underlying Children's Responses to Food Portion Size and Energy Density

Increased portion sizes of foods high in energy density (calories per gram of food) have been implicated in the obesity epidemic. Numerous studies show that children and adults eat more from larger portions of food than they do from smaller portions, a response known as the portion size effect. Despite the robust and consistent nature of these findings, the mechanisms underlying the portion size effect are not known. The long-term goal of this research is to identify the neural mechanisms involved in the portion size effect so that this information can be used to develop effective weight-management strategies. Differences in neural response to food cues, as demonstrated by functional magnetic resonance imaging (fMRI), can help clarify the factors that determine susceptibility to large portions. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.

The investigators hypothesize that high relative to low energy density food images will be associated with increased activation in regions of the brain involved in reward- and sensory- processing and that large relative to small portion size food images will be associated with increased activation in regions of the brain involved in cognitive control. In addition, the investigators hypothesize that these brain responses will influence the relationship between portion size served and energy intake at laboratory meals.

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Key information

About this study

What this study will add to the literature: The response to food images that vary by portion size using fMRI has not been previously reported. Furthermore, how the brain response to food portion size and energy density is related to energy intake has not been previously reported. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Right-handedness
  • English as native language
  • Reading at /above grade level
  • Not claustrophobic
  • Generally healthy

Exclusion criteria

  • Left-handedness
  • Metal in or on the body that cannot be removed
  • Claustrophobic
  • Medication usage that could alter brain activity
  • Medical disorder that may impact comfort in scanner
  • Food allergies

Treatment and study plan

Primary outcomes

  1. fMRI blood oxygen level dependent (BOLD) response to food portion size and energy density

    Time frame: Collected at fMRI scan (1 of 1) at week 5

    Whole-brain response to food images that varied at 2 levels of portion size and 2 levels of energy density

  2. Energy intake

    Time frame: Collected at week 1, 2, 3, and 4

    Energy intake (kcal and grams) of foods consumed ad libitum at each laboratory test-meal in response to 4 conditions of portion sizes (100% reference, 133%, 167%, 200%).

Secondary outcomes

  1. Region of Interest (ROI)-response to food portion size and energy density

    Time frame: Collected at fMRI scan (1 of 1) at week 5

    Response in selected brain regions of interest to food images varied at 2 levels of portion size and 2 levels of energy density

Other outcomes

  1. Appetitive traits

    Time frame: Collected at week 1 (Baseline)

    Parent-reported questionnaire of habitual eating styles in children

  2. Body composition a/o weight status

    Time frame: Collected at week 1 (Baseline)

    Height, weight and body fat percentage were measured. Body mass index (BMI), BMI z score, fat-mass index and fat-free-mass index will be calculated.

  3. Liking of foods

    Time frame: Collected at week 5

    Ratings of how much child likes food presented on a computerized visual analog scale

  4. Wanting of foods

    Time frame: Collected at week 5

    Ratings of how much child wants food presented on a computerized visual analog scale

  5. Loss of control eating

    Time frame: Collected at week 1 (Baseline)

    Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.

  6. Parental feeding strategies

    Time frame: Collected at week 1 (Baseline)

    Parent-reported measures of feeding practices

Sponsors and collaborators

Lead sponsor

Penn State University

Other

Collaborators

  • Social Science Research Institute

Registry information

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
May 3, 2016
Registry last updated
Dec 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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