Max Planck UCL Centre for Computational Psychiatry and Ageing Research
London, WC1B 5EH, United Kingdom
Location status: Recruiting
Location contact
Karen Hoang, MSc
CONTACT
Tricia Seow, PhD
CONTACT
Recruiting
NCT Number: NCT05520398
Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy.
To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year–55 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP).
In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks).
To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms.
The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Diagnosis of obsessive-compulsive disorder (OCD)
- Fluent in written and spoken English
- Normal/corrected to normal vision
- Expecting to start OCD therapy
Exclusion criteria
- Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder
- Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids
- Colour blindness
- Severe learning disabilities
Treatment and study plan
Primary outcomes
-
Yale-Brown obsessive compulsive scale (Y-BOCS)
Time frame: 3 - 9 months
The Y-BOCS is a 10-item scale used to assess symptom severity in OCD.
-
Decision making and learning tasks
Time frame: 3 - 9 months
Computer-based behavioural task developed by the investigators to understand decision making in OCD.
Secondary outcomes
-
Patient EX/RP Adherence Scale (PEAS)
Time frame: 3 - 9 months
Self-report assessment for patient's therapy adherence.
-
Short form of Obsessive Beliefs Questionnaire (OBQ)
Time frame: 3 - 9 months
Self-report assessment for obsessive beliefs.
-
Brief Experiential Avoidance Questionnaire (BEAQ)
Time frame: 3 - 9 months
Self-report assessment for experiential avoidance.
-
International Cognitive Ability Resource (ICAR16)
Time frame: 3 - 9 months
Measure to assess cognitive ability.
-
Worry Domains Questionnaire - Short Form (WDQ-SF)
Time frame: 3 - 9 months
Self-report assessment for worry.
-
The World Health Organization Quality of Life Brief Version (WHOQOL-BREF)
Time frame: 3 - 9 months
Self-report assessment for quality of life assessment.
-
Sheehan Disability Scale (SDS)
Time frame: 3 - 9 months
Self-report assessment for functional impairment.
-
State-Trait Anxiety Inventory (STAI)
Time frame: 3 - 9 months
Measure of trait and state anxiety
-
Zung Self-Rating Depression Scale (SDS)
Time frame: 3 - 9 months
Self-report measure of depressive symptomatology.
-
Anxiety Sensitivity Index (ASI-3)
Time frame: 3 - 9 months
Self-report measure for anxiety sensitivity symptomatology.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University College, London
Other
Registry information
Official study title
Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)
Acronym: ERP in Silico
Important dates
- Study start
- 2021
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Aug 29, 2022
- Registry last updated
- Dec 19, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Related clinical trials
Published trials that share one or more normalized conditions with this study.
Recruiting
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
NCT07347405
Anxiety Disorders, Mental Disorders
Tucson, Arizona, United States
View Trial Details
Recruiting
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder
NCT07701616
Anxiety Disorders, Mental Disorders
Changsha, Hunan, China
View Trial Details
Recruiting
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
NCT06376734
Anxiety Disorders, Behavior
Sunnyvale, California, United States
View Trial Details
Recruiting
Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD)
NCT07704632
Anxiety Disorders, Mental Disorders
Toronto, Ontario, Canada
View Trial Details