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Active, Not Recruiting

NCT Number: NCT03487224

Neural Mechanisms of Decision Making in Hoarding Disorder

The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University

Stanford, California, 94305, United States

About this study

Hoarding disorder is a common and disabling disorder that represents a significant public health problem. This study aims to build on current research on decision making by examining these processes in hoarding disorder.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Identify inclusion criteria.

Inclusion criteria

for participants diagnosed with HD:

  • ages 18-70
  • primary diagnosis of hoarding disorder
  • sufficient severity of hoarding symptoms
  • stable on psychotropic medications for 1 month prior to study enrollment
  • capacity to provide informed consent
  • ability to tolerate clinical study procedures

Inclusion criteria

for healthy control participants:

  • ages 18-70
  • capacity to provide informed consent

Identify exclusion criteria.

Exclusion criteria

for participants with HD:

  • psychiatric or medical conditions that make participation unsafe
  • pregnant or nursing females
  • concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
  • presence of metallic device or dental braces

Exclusion criteria

for healthy control participants:

  • any current or lifetime psychiatric diagnosis
  • current or past use of psychotropic medication
  • pregnant or nursing females
  • major medical or neurological problem
  • presence of metallic device or dental braces

Treatment and study plan

MRI with fMRI frequency

Device

Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.

Primary outcomes

  1. BOLD signal

    Time frame: up to 90 minutes

    BOLD signal derived from fMRI

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Acronym: LOSS

Important dates

Study start
2018
Primary completion
2026
Study completion
2026
First posted
Apr 3, 2018
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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