Neural Correlates of Self Body-shape Recognition in Anorexia Nervosa Mental

Body Image distortion is a key diagnostic feature for Anorexia Nervosa. Patients suffering from Anorexia Nervosa tend to perceive themselves as fatter than they are. This bias might be at the origin of a reinforcement of anorectic behavior which might alter medical care. The objective of this study is to identify neural correlates of self-recognition in Anorexia Nervosa. Patients are hypothesized to activate the self-recognition network when seeing images of a fatter body shape than their own.

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Key information

Conditions

Anorexia Nervosa Feeding and Eating Disorders Mental Disorders

Age range

15 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

CHRU,Hôpital Fontan 2

Lille, France

About this study

Patients suffering from Anorexia Nervosa and control subjects (matched by age and study level) are recruited in medical care facilities in Lille's Metropolis. They are asked to identify their body shape when being presented with 3 different stimuli, i.e.real (RBS), estimated (EBS) and neutral body shape (NBS), in a functional magnetic resonance imaging or functional MRI (fMRI) machine. While answering to this identification paradigm, we hoped to identify modifications in the self body-recognition network.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Providing informed, dated and signed consent (for minors, consent must be signed by both parents)
With medical insurance
With normal vision
Only for the AN Group : Diagnosis of Anorexia Nervosa (AN) restrictive for at least one year and with a Body Masse index (BMI) between 14 and 18
Only for the control Group : BMI between 18 and 25 and without any psychiatric disorder

Exclusion criteria

Pregnant or breast-feeding women
With antecedent or current neurologic disease
With antecedent or current ophthalmologic disease
Contraindication for IRMf

Treatment and study plan

Primary outcomes

Measure of the activation brain areas in self body-recognition network

Time frame: 15 days

Level of activation areas in the self body-recognition network measured during fMRI

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Neural Correlates of Self Body-shape Recognition in Anorexia Nervosa, an fMRI Activation Study

Acronym: Explorexie

Important dates

Study start: 2013
Primary completion: 2020
Study completion: 2020
First posted: Jan 10, 2019
Registry last updated: Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed