Deep brain stimulation
DeviceDeep brain stimulation will be used
Recruiting
NCT Number: NCT04874220
Neural Correlates of Real World Spatial Navigation in Humans
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
12 year–70 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
University of California, Los Angeles, Los Angeles, California, United States
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Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- 12 years of age or older and has undergone RNS system placement
- Willing to provide informed consent and participate the study
- Ability to read and write English fluently
Exclusion criteria
- Unwilling to provide informed consent
Treatment and study plan
Memory and spatial navigation tasks
BehavioralTasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity.
Physiological Signals
BehavioralPhysiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used.
Questionnaires and Assessments
BehavioralParticipants complete questionnaires and assessments to assess subjective emotional experience.
Primary outcomes
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Spatial memory
Time frame: Throughout study completion, an average of 2-4 days per year
Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks).
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Memory performance change
Time frame: Throughout study completion, an average of 2-4 days per year
Memory performance will be measured using excess path length, latency, and accuracy rate.
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Oscillatory activity change
Time frame: Throughout study completion, an average of 2-4 days per year
Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment.
Study contacts
Contact information is provided by the study sponsor or research team.
Gabriela Vilchez
CONTACT
Nanthia Suthana, PhD
CONTACT
Sponsors and collaborators
Lead sponsor
Duke University
Other
Collaborators
- National Institute of Mental Health (NIMH)
- National Institute of Neurological Disorders and Stroke (NINDS)
Registry information
Important dates
- Study start
- 2020
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- May 5, 2021
- Registry last updated
- May 15, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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