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OpenTrials
Completed

NCT Number: NCT01701180

Neural Correlates of Empathogenic and Affiliative Actions of Oxytocin

Mounting evidence indicates that the intranasal administration of the neuropeptide oxytocin has prosocial effects. However, the neural substrates of these effects are still unclear. The investigators hypothesized that a single dose administration of oxytocin should increase empathogenic and affiliative responses and that these effects are mediated by an increased insula activity.

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Key information

Conditions

Healthy

Age range

18 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Early Phase 1

Primary location

Department of Psychiatry, University of Bonn

Bonn, North Rhine-Westphalia, 53105, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male volunteers
  • In a heterosexual relationship

Exclusion criteria

  • Current or past psychiatric disease
  • Current or past physical illness
  • Psychoactive medication
  • Tobacco smokers

Treatment and study plan

Oxytocin

Drug

24 IU; 3 puffs per nostril, each with 4 IU OXT

Other names: Oxytocin: Syntocinon-Spray, Novartis

Placebo

Drug

Primary outcomes

  1. Empathy ratings and their neural correlates

    Time frame: About one hour after the intranasal administration of oxytocin

    All subjects are scanned while they view emotional and neutral faces and rate their empathy for these stimuli.

Secondary outcomes

  1. Neural correlates of pair-bonding

    Time frame: About one hour after the intranasal administration of oxytocin

    All subjects are scanned while they view a picture of their mate and and an unknown female.

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Neural Correlates of the Empathogenic and Affiliative Actions of Oxytocin

Acronym: ODIS

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Oct 4, 2012
Registry last updated
Dec 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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