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Completed

NCT Number: NCT00264407

Neural Changes in the Aging Auditory System

The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.

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Key information

Conditions

Progesterone Auditory Diseases, Central Auditory Perceptual Disorders Brain Diseases Central Nervous System Diseases Cognition Disorders Ear Diseases Estrogens Hearing Hearing Disorders Hearing Loss Hearing Loss, Bilateral Hearing Loss, Central Hearing Loss, Sensorineural Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Perceptual Disorders Presbycusis Psychoacoustics Retrocochlear Diseases Sensation Disorders Signs and Symptoms

Age range

60 year–86 year

Sex eligibility

Female

Study type

Observational

Primary location

International Center Hearing & Speech Research - NTID - RIT, Rochester, New York, United States

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About this study

Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.

Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy middle ears

Exclusion criteria

  • ototoxic medications
  • serious medical health problems
  • neurological conditions
  • Meniere's disease or labyrinthitis
  • those who failed cognitive screening tests (Mini-Mental Test)
  • current/heavy smokers
  • conductive hearing loss
  • history of noise damage and/or audiograms signifying noise damage
  • poor speech discrimination scores (80% or less)

Treatment and study plan

Hormone Replacement Therapy - HRT

Drug

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Collaborators

  • National Institute on Aging (NIA)
  • National Institute on Deafness and Other Communication Disorders (NIDCD)
  • Rochester Institute of Technology

Registry information

Official study title

Age-Related Hearing Loss: Presbycusis & Its Neural Bases

Important dates

Study start
2001
Study completion
2005
First posted
Dec 12, 2005
Registry last updated
Dec 12, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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