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NCT Number: NCT06764290

Neural Changes in Stroke Patients During Challenging Walking Tasks.

For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered.

Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Geriatric Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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About this study

Stroke participants will wear a 32-lead electroencephalogram electrode cap (Zhentai Technology Company, Xi 'an, China), first walk on a flat ground for 60 seconds, rest for 2 minutes, then walk on the pedal for 60 seconds, rest again for 2 minutes, and walk for 60 seconds with eyes-covered.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke
  • Disease duration of more than 14 days， less than 1 year
  • Able to walk independently but with a lingering abnormal gait

Exclusion criteria

  • Lesions accumulate in the brainstem
  • Lesions accumulate in the cerebellum
  • Impaired vision
  • Severe cognitive impairment

Treatment and study plan

pedal walking

Other

Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants.

visual occlusion

Other

Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.

Primary outcomes

  1. Weight Phase Lag Index

    Time frame: The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds

    The Weighted Phase Lag Index (WPLI) is a measure used to quantify phase synchronization in electrophysiological data.Continuously measure the connectivity of the coupling of neural oscillatory activity in the brain, while being statistically more powerful in detecting changes in signal phase synchronization.The WPLI ranges from 0 to 1, with 0 indicating no phase synchronization and 1 indicating complete phase synchronization.

  2. Relative power

    Time frame: The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds

    The electroencephalogram signal in the time domain is converted into the relevant information in the frequency domain, the frequency bands are divided, and the relative power results of each channel in each frequency band are derived. Among them, delta:1-4Hz, theta:4-8Hz, alpha:8-15Hz, beta:15-30Hz, gamma:30-45Hz.

Study contacts

Contact information is provided by the study sponsor or research team.

Jing Zhao, master

CONTACT

[email protected]

+8618817892579

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Registry information

Official study title

Neural Mechanism Changes in Stroke Patients During Challenging Environments

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 8, 2025
Registry last updated
Jan 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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