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Completed

NCT Number: NCT02997475

Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa

The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

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Key information

Conditions

Bulimia Nervosa Behavior Bulimia Emotional Regulation Feeding and Eating Disorders Hyperphagia Mental Disorders Pathological Conditions, Signs and Symptoms Self-Control Signs and Symptoms Signs and Symptoms, Digestive Social Behavior

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

UCSD Eating Disorders Center for Treatment and Research

San Diego, California, 92121, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

General Inclusion Criteria:

  • Female
  • Right-handed
  • Between the ages of 18 and 35 years

*For Women with Bulimia Nervosa:

  • Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control)
  • Purging via self-induced vomiting (other methods may also be endorsed)

General Exclusion Criteria:

  • Current significant medical illness or condition (e.g., diabetes, thyroid disease)
  • Pregnancy, planned pregnancy, or lactation during the study period
  • Non-removable metallic objects in the body

Treatment and study plan

Primary outcomes

  1. Self-Regulatory Control

    Time frame: Day 2 (fMRI Scan)

    Functional Magnetic Resonance Imaging will be used to assess brain activation associated with motor inhibitory control and affect regulation in women with bulimia nervosa (BN)

Secondary outcomes

  1. Goal-Directed Action Control

    Time frame: Day 1

    An computerized instrumental learning task will be used to assess performance of women with and without bulimia nervosa.

  2. Eating Disorder Relevance

    Time frame: Day 0

    The Eating Disorder Examination (EDE) will be conducted to assess relative associations of motor, affective, and goal-directed action control with bulimia nervosa severity.

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Collaborators

  • National Institute of Mental Health (NIMH)
  • The Hilda & Preston Davis Foundation

Registry information

Acronym: SRBN

Important dates

Study start
2016
Primary completion
2022
Study completion
2022
First posted
Dec 20, 2016
Registry last updated
Jan 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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