Neural and Behavioural Bases of Action Simulation

The goal of this interventional study is to understand the neural and behavioural bases of action simulation and its links with action execution in healthy volunteers.

Hypotheses: Action simulation recruits neural networks that are largely similar to those activated by action execution, with some differences to avoid executing a movement while observing/imagining it.

Participants will be tested with TMS while doing motor imagery or action observation.

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Key information

Conditions

Healthy Participants

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy adult volunteers (more than 18 years old)

Exclusion criteria

Participants taking anti-epileptic drugs
pregnant or breastfeeding women cannot participate in this study
people with a pacemaker
people with a cochlear implant
people with a metal part in the brain or any other medical implant in their body (pump, neurostimulator, valve,) cannot take part in this study.

Treatment and study plan

Transcranial Magnetic Stimulation Sham

Device

Participants will be asked to perform various behavioral tasks involving the use of action observation or motor imagery. During these tasks, transcranial magnetic stimulation will be used.

Primary outcomes

Motor Evoked Potential (MEP)

Time frame: For the duration of the participants' visit to the laboratory (max 2h30)

Evoked motor potentials will be measured throughout the experiment using surface electrodes on different muscles to measure changes in corticospinal excitability.

Sponsors and collaborators

Lead sponsor

Université Catholique de Louvain

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: Feb 20, 2025
Registry last updated: Feb 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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