Nerve Growth Factor in Chronic Pancreatitis

This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis.

Hypothesis:

1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem 2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.

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Key information

Conditions

Chronic Pancreatitis Chronic Disease Digestive System Diseases Disease Attributes Pancreatic Diseases Pancreatitis Pancreatitis, Chronic Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Virginia Commonwealth University Medical Center

Richmond, Virginia, 23298, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with established CP and none of the exclusion criteria mention below.

Exclusion criteria

Failure to obtain consent.
Any comorbid condition with expected survival < 1 year.
Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
Patients < 18 years of age at time of consent

Treatment and study plan

Primary outcomes

The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores.

Time frame: 5 years

Secondary outcomes

Correlate the expression of NGF and other inflammatory cytokines in the pancreatic juice in each morphological stage of CP.

Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Virginia Commonwealth University

Other

Collaborators

Stanford University

Registry information

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Dec 8, 2010
Registry last updated: Mar 7, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed