Nerve Changes in Patients Who Are Undergoing Chemotherapy or Biological Therapy for Cancer

OBJECTIVES:

• Determine the change in peripheral nerve function in cancer patients during and after treatment with chemotherapy or biologic therapy.
• Determine the clinical measurement of hearing-related air and bone conduction and vibratory sensation in these patients.
• Correlate the changes in orthostatic blood pressure using both the Vasotrac automated blood pressure device and the standard clinical automated blood pressure equipment.
• Determine the patient's perception of hearing quality before and after treatment with chemotherapy or biologic therapy.

OUTLINE: This is a multicenter study.

Patients undergo a 1-hour peripheral nerve function assessment, including hearing, vibratory sensation, and blood pressure testing, at baseline and then at 4, 8, and 12 weeks during treatment with chemotherapy or biologic therapy.

PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

• Histologically confirmed diagnosis of cancer
• Scheduled to be treated with 1 of the following agents:

• Cisplatin/paclitaxel combination
• Biologic therapy with high-dose interferon alfa

PATIENT CHARACTERISTICS:

• Normal vision OR vision corrected with glasses or contact lenses
• No diseases or disorders reducing peripheral nerve function, including any of the following:

• Diabetes mellitus
• HIV/AIDS
• Uremia
• Spinal injuries
• Alcoholism
• CNS problems
• No hearing impairment

PRIOR CONCURRENT THERAPY:

• No prior biologic therapy or neurotoxic chemotherapy