Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma Beyond Milan/UCSF Criteria Who Underwent Liver Transplantation

Inclusion criteria

• older than 18 years old and younger than 75 years listed for liver transplant;
• ECOG PS≤1;
• Child-Pugh Stage A or B
• Proven hepatocellular carcinoma according patological examination or EASL/AASLD diagnostic criteria;
• Not previous treated for tumor;
• The tumor was diagnosed beyond Milan criteria or University of San Francisco criteria for LT
• No distant metastasis;
• The lab test could meet:

Neutrophil count≥2.0×109/L; Hemoglobin≥100g/L; Platelet count≥75×109/L; Serum albumin≥35g/L; Total bilirubin<2-times upper limit of normal; ALT<3-times upper limit of normal; AST<3-times upper limit of normal; Serum creatine<1.5-times upper limit of normal; PT≤upper limit of normal plus 4 seconds; INR≤2.2;

• Sign up consent.

Exclusion criteria

• Cannot tolerate TAI or LT;
• Distant metastasis exits;
• Known history of other malignancy;
• Be allergic to related drugs;
• Be treated before (interferon included);
• Known history of HIV infection;
• Known history of drug or alcohol abuse;
• Have GI hemorrhage or cardiac/brain vascular events within 30 days;
• Pregnancy.