Near Infrared Fluorescence Imaging With Indocyanine Green

This research study is a pilot test of the effectiveness of a near infrared fluorescence imaging (NIFI) system in the detection and diagnosis of pulmonary nodules. Patients selected for enrollment in this study will be adults (≥18 years) that have been scheduled for surgical biopsy and/or resection of a primary lung nodule identified by prior imaging. Patients will receive an injection of indocyanine green (ICG) contrast dye one day prior to their surgery. Intraoperatively, the NIFI system will be used to visualize and characterize the fluorescence patterns given off by these lung nodules, as well as look for additional undiagnosed nodules. These nodules will then be resected and receive histological characterization, as per standard of care. The NIFI system will be evaluated for its ability to 1) visualize nodules and their margins 2) differentiate between benign and malignant nodules and 3) identify additional undiagnosed nodules.

Inclusion criteria

• Subjects must be willing to undergo surgical biopsy and/or resection of pulmonary nodule(s).
• Women and men at least 18 years of age
• Subjects must have a CT scan of the chest within 8 weeks of surgery

Exclusion criteria

• Previous thoracic surgery
• Inoperable tumor/nodule
• Unable to tolerate surgery
• History of allergies to iodides
• Breast feeding
• Pregnant