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NCT Number: NCT07662915

NCMT Technique and Jodhpur Technique and Excimer Laser in Treatment of Non Vitiligo Leucoderma

This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of stable non-vitiligo leukoderma. Twenty-two patients with stable depigmented lesions will be enrolled. In each patient, two comparable lesions will be treated using different techniques. Clinical outcomes including percentage of repigmentation, color match, time to onset of repigmentation, complications, and histological changes will be assessed during follow-up to determine the optimal surgical treatment approach for non-vitiligo leukoderma.

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Key information

Conditions

Leukoderma Hypopigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases Vitiligo

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 to 60 years.
  • Clinically diagnosed stable non-vitiligo leukoderma.
  • Stable lesion(s) for at least 6 months with no progression.
  • Inadequate response to conventional medical therapy.
  • Presence of two comparable lesions
  • Willingness to participate and provide written informed consent.

Exclusion criteria

  • Vitiligo or suspected active vitiligo.
  • History of keloid or hypertrophic scar formation.
  • Active infection at donor or recipient sites.
  • Bleeding disorders or anticoagulant therapy that cannot be safely discontinued.
  • Pregnancy or lactation.
  • Immunosuppression or uncontrolled systemic disease.
  • Inability to comply with follow-up visits.
  • Unrealistic expectations regarding treatment outcome.

Treatment and study plan

Melanocyte Keratinocyte Transplantation Procedure (MKTP)

Procedure

Autologous melanocyte-keratinocyte cell suspension prepared using enzymatic separation and applied to a dermabraded recipient site.

Jodhpur Technique

Procedure

Autologous non-cultured epidermal cell transfer technique using dermabraded donor skin particles applied directly to the recipient site without enzymatic processing

308-nm Excimer Laser

Device

Excimer laser therapy initiated approximately 14 days after surgery, administered twice weekly for 12-16 weeks with dose adjustment according to erythema response

Primary outcomes

  1. Mean Percentage Repigmentation of Target Lesions

    Time frame: 6 months

Secondary outcomes

  1. Time to Onset of Repigmentation

    Time frame: Up to 6 months

  2. Color Match Assessment

    Time frame: 6 months

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed Mahmoud

CONTACT

[email protected]

+201091865997

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Efficacy and Safety of Melanocyte Keratinocyte Transplantation Procedure Plus 308-nm Excimer Laser in the Treatment of Non-Vitiligo Leukoderma

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Jun 23, 2026
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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