Natural History of Hepatitis C in Patients With Normal Liver Tests

The Major goals of this project was to assess the natural history of disease in chronic hepatitis C patients with normal ALT and to determine the virologic and host factors associated with disease severity.

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Key information

Conditions

Chronic Hepatitis C Blood-Borne Infections Chronic Disease Communicable Diseases Digestive System Diseases Disease Attributes Flaviviridae Infections Hepatitis Hepatitis C Hepatitis C, Chronic Hepatitis, Chronic Hepatitis, Viral, Human Infections Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms RNA Virus Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with chronic hepatitis C and persistently normal liver enzymes
able to give consent

Exclusion criteria

decompensated liver disease
any prior antiviral or immunosuppressive therapy
other liver disease besides hepatitis C

Treatment and study plan

Liver biopsy

Procedure

Liver biopsy every 5 years

Primary outcomes

ALT

Time frame: March 2015

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

Determinants of Disease Severity in Patients With Chronic Hepatitis C and Normal Serum Aminotransferases (Normal Liver Tests)

Important dates

Study start: 2000
Primary completion: 2021
Study completion: 2021
First posted: Sep 16, 2005
Registry last updated: Jan 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed