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OpenTrials
Completed

NCT Number: NCT00918541

Natural History of Atherosclerosis

20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Disease Attributes Disease Progression Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Ospedale San Giovanni, Bellinzona, Switzerland

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • stable carotid artery disease not requiring revascularization
  • asymptomatic carotid artery stenosis < 80% or symptomatic patients with stenosis < 60 %
  • prophylactic therapy with aspirin (> 100mg/day, statin, blood pressure therapy if indicated (goal < 130/80 mmHg))
  • informed consent

Exclusion criteria

  • non atherosclerotic occlusive disease (Bürgers disease)
  • uncontrolled BP (DBP > 110 mmHg and/or SBP > 200 mmHg)
  • hemorrhagic disease or platelet count < 100'000 mm^3
  • Known active liver disease (elevations of GPT GOT or increased ammonia)
  • impaired renal function (crea > 180 mmol/l)
  • pregnancy
  • severe claustrophobic reactions
  • short - term life - threatening pathology
  • physically unable to participate in the study
  • compliance not guaranteed

Treatment and study plan

Primary outcomes

  1. Progression of atherosclerotic plaque

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • Districthospital of Bellinzona

Registry information

Official study title

Natural 1-year History of Atherosclerosis in Asymptomatic Patients With Mild to Moderate Carotid Stenosis

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Jun 11, 2009
Registry last updated
Dec 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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