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Completed

NCT Number: NCT00942786

Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.

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Key information

Conditions

Surgery

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesia and Intensive Care Medicine

Graz, 8036, Austria

About this study

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Emergency surgery:
  • Vascular
  • Intra-abdominal
  • Orthopedic

Exclusion criteria

  • Patients unable to provide informed consent
  • Thoracic surgery
  • Trauma surgery

Treatment and study plan

Primary outcomes

  1. Occurence of Adverse Cardiac Events

    Time frame: postoperatively (index surgery) until a median follow-up of 34 months

    Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death).

    Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality.

    Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.

Other outcomes

  1. NT-ProBNP Preoperative

    Time frame: 0-24 hours before induction of anesthesia

    NT-ProBNP was measured 0-24 hours before induction of anesthesia

  2. Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events

    Time frame: postoperatively (index surgery) until a median follow-up of 34 months

    Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

Important dates

Study start
2008
Primary completion
2014
Study completion
2014
First posted
Jul 21, 2009
Registry last updated
Jun 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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