Natriuretic Peptides After Left Atrial Appendage Amputation

Surgical amputation of the left atrial appendage (LAA) is an established intervention during surgical atrial fibrillation (AF) therapy. However, its effects on the endocrine function of the left atrium are unclear. This study aims to quantify the serum levels of natriuretic peptides in patients who undergo concomitant surgical AF ablation with or without LAA amputation.

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Adult and Pediatric Cardiovascular Surgery

Giessen, 35392, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Indication for concomitant AF therapy during cardiac surgery with cardiopulmonary bypass

Exclusion criteria

Lack of informed consent

Treatment and study plan

LAA amputation

Procedure

complete surgical amputation of the left atrial appendage

Primary outcomes

Serum levels of proANP and BNP until 800days post surgery

Time frame: 800days

Sponsors and collaborators

Lead sponsor

University of Giessen

Other

Registry information

Official study title

Influence of Left Atrial Appendage Amputation on Natriuretic Peptides - a Randomized Controlled Trial

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2018
First posted: Jan 25, 2019
Registry last updated: Jan 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed