National Multicenter Cohort Registry Study of Rapid rEcurrences of Coronary Unexplained In-stent Restenosis

Inclusion criteria

• Age ≥ 18 years;
• Patients meeting the diagnostic criteria for Rapid rEcurrences of Coronary Unexplained in-stent Restenosis (RECUR);
• Patients fully informed about the trial procedures who provide written informed consent.

Exclusion criteria

• Patients presenting with any of the following:

• Other severe comorbidities (e.g., malignant tumors, heart failure) with a life expectancy <12 months;

• Known autoimmune/rheumatic diseases including systemic lupus erythematosus, Takayasu arteritis, Behçet's disease, polyarteritis nodosa, Wegener granulomatosis (granulomatosis with polyangiitis), eosinophilic arteritis, giant cell arteritis, rheumatoid arthritis, or IgG4-related disease;

• Variant angina (Prinzmetal's angina);

• Coronary artery dissection;

• Thrombophilia;

• Stent underexpansion.
• Presence of psychiatric disorders;
• Known inability to complete expected study follow-up for any reason;
• Patients deemed ineligible for enrollment by the investigator.