Nasolacrimal Sac Biopsy in Endoscopic Dacryocystorhinostomy

During dacryocystorhinostomy (DCR), the lacrimal sac wall biopsy is not routinely performed, but it is recommended if there is a suspicion of underlying disease other than preoperatively or intraoperatively chronic inflammation. We aimed to evaluate the utility of the histopathology examination of fifty patients in AlAzhar Hospitals to put recommendation for histopathology examination of such cases.

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Key information

Conditions

Dacryocystitis; Chronic Bronchial Diseases Bronchiolitis Bronchiolitis Obliterans Bronchiolitis Obliterans Syndrome Bronchitis Dacryocystitis Eye Diseases Graft vs Host Disease Immune System Diseases Lacrimal Apparatus Diseases Lung Diseases Lung Diseases, Obstructive Organizing Pneumonia Respiratory Tract Diseases

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Azhar faculty of medicine

Cairo, 11884, Egypt

About this study

Most of patient with epiphora have different causes of nasolacrimal duct obstruction . This study aims to examine how important routine lacrimal sac biopsy is during endoscopic dacryocystorhinostomy surgery.

The study included 50 patients with chronic unilateral epiphora. All patients underwent endoscopic dacryocystorhinostomy with nasolacrimal duct biopsy. Histopathologic analysis was performed for each specimen to assess the nature of the pathology.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male and female patients with chronic lacrimal duct obstruction attended the outpatient clinic of the hospital for treatment during the study period.

Exclusion criteria

Patients refusing the biopsy
Patients asked for histopathology in private laboratories

Treatment and study plan

biopsying

Diagnostic Test

The procedure was carried out under general or local anesthesia. An otolaryngologist conducts the endoscopic intranasal operation, while an eye surgeon removes tissue from the sac and lacrimal tubes using lacrimal probes passed through the canaliculi.

Primary outcomes

Microscopic examination using Hematoxylin and Eosin stains with special stain

Time frame: fourteen days

sending the biopsies to the pathology laboratory with completed request form then examination of the biopsies in the laboratory using the light microscope to assess the nature of the lesion with degree of inflammation according to the amount of lymphocytes to be classified as mild (10% cells), moderate (up to 50%) or severe (more than 50% lymphocytic cells)

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Predictive Value of Nasolacrimal Sac Biopsy in Endoscopic Dacryocystorhinostomy

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2021
First posted: Mar 11, 2021
Registry last updated: Mar 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed