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NCT Number: NCT07395778

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance.

The main question it tries to answer is

1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis 2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group

Recruiting

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Key information

Conditions

Walled Off Pancreatic Necrosis Acute Pancreatitis (AP) Digestive System Diseases Endoscopic Ultrasound-Guided Drainage Pancreatic Diseases Pancreatitis

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Post Graduate Institute of Medical Education and Research (PGIMER)

Chandigarh, 160012, India

Location status: Recruiting

Location contact

Saurabh Kumar Singh, MD

PRINCIPAL_INVESTIGATOR

Surinder Singh Rana, DM

CONTACT

[email protected]

+919560113930

Surinder Singh Rana, DM

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of acute pancreatitis (AP) with 18-75 years of age
  • Patients with symptomatic WON requiring EUS guided transluminal drainage
  • Provision of written informed consent

Exclusion criteria

  • Patients with collection not amenable for EUS guided drainage (distance of WON >1 cm from the gastrointestinal lumen)
  • Known malignancy or immunocompromised state
  • Previous upper gastrointestinal(GI) surgery interfering with absorption
  • Active GI bleeding
  • GI obstruction, ileus or persistent vomiting
  • Patients moribund to undergo endoscopic procedure (Glasgow coma scale <8 or patients on ventilatory support)
  • Patients with irreversible coagulopathy like platelets <50,000/mm3 and/or INR>1.5
  • Pregnant or lactating female

Treatment and study plan

endoscopic ultrasonography guided cystogastrostomy

Procedure

Nasojejunal tube will be placed post EUS-CG or oral diet would be started after randomization

Primary outcomes

  1. Nutritional failure

    Time frame: 14 days

    To compare the rate of nutritional failure at Day 14 between Nasojejunal and oral feeding post endoscopic transmural drainage of WON

Secondary outcomes

  1. Infection and new onset organ failure

    Time frame: 14 days

    To compare infection rates, need for antibiotic escalation and new onset organ failure

  2. Re-intervention needs

    Time frame: 14 days

    To compare the need for re-intervention and hospital stay duration in either of the group

  3. Change in weight

    Time frame: 14 days

    To compare patient weight

  4. Inflammatory markers

    Time frame: 14 days

    To compare change in inflammatory markers (CRP, Serum Albumin)

Study contacts

Contact information is provided by the study sponsor or research team.

Saurabh Kumar Singh

CONTACT

[email protected]

+919560113930

Sponsors and collaborators

Lead sponsor

Post Graduate Institute of Medical Education and Research, Chandigarh

Other

Registry information

Official study title

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis: A Randomized Controlled Pilot Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Feb 9, 2026
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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