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NCT Number: NCT00569361

Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic Disease

Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups:

1. allergic rhinitis to dust mite (AR) isolated (n=12), 2. AR associated with bronchial hyperreactivity (n=12), 3. AR associated with asthma (n=14), 4. control (n=14).

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Key information

Conditions

Allergic Rhinitis Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Nose Diseases Otorhinolaryngologic Diseases Respiratory Hypersensitivity Respiratory Tract Diseases Rhinitis Rhinitis, Allergic

Age range

6 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Pediatrics, Nice University Hospital

Nice, 06000, France

About this study

Context: Asthma is the most frequent chronic disease in childhood. Allergic rhinitis has been described as a risk factor to develop asthma. The objective of the study was to evaluate the contribution of the respiratory epithelium to development of allergic rhinitis and asthma and to identify the molecular mechanisms driving rhinitis toward asthma.

Methods: Using a human pangenomic microarray, we established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct children 2 to 18 years of age groups:

  • allergic rhinitis to dust mite (AR) isolated (n=12),
  • AR associated with bronchial hyperreactivity (n=12),
  • AR associated with asthma (n=14),
  • control (n=14).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients:

  • Patients between 6 and 17 years old
  • Patients with allergic rhinitis

Witness:

  • Patients between 6 and 17 years old
  • Patients without allergic rhinitis and asthma

Exclusion criteria

  • Rhino-bronchitis infection dated from less than 15 days
  • Patients younger than 6 or older than 17 years

Treatment and study plan

Collection of nasal epithelial cells

Procedure

Collection of nasal epithelial cells by brushing

Primary outcomes

  1. Transcriptome analysis: genes statistically modulated between groups, predictive biomarkers allowing correct classification of groups

    Time frame: At the sample time

Secondary outcomes

  1. Validation with other techniques: Q-PCR

    Time frame: At the sample time

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Collaborators

  • ADPHUN, FRM

Registry information

Official study title

Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic

Important dates

Study start
2004
Study completion
2005
First posted
Dec 7, 2007
Registry last updated
Jun 9, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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