Nasal Decongestion and Obstructive Sleep Apnea

Whether impaired nasal breathing contributes to sleep related breathing disturbances has not been known. Therefore, the purpose of the study is to compare the effect of xylometazoline, a drug that decongests the nasal mucosa when applied locally, with placebo in terms of sleep and nocturnal breathing and daytime performance.

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Key information

Conditions

Obstructive Sleep Apnea Syndrome Apnea Dyssomnias Infections Nervous System Diseases Nose Diseases Otorhinolaryngologic Diseases Respiration Disorders Respiratory Tract Diseases Respiratory Tract Infections Rhinitis Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Pulmonary Division, University Hospital Zurich, Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Obstructive sleep apnea syndrome (excessive sleepiness, apnea/hypopnea index >10/h)
Chronic nasal congestion (complaint of impaired nasal breathing that interfered with subjective sleep quality on at least 3 nights per week during at least the last 3 months)

Exclusion criteria

Nasal surgery within the last 6 months
Current treatment with nasal decongestants or topical steroids
Sleep disorders other than obstructive sleep apnea
Internal medical or psychiatric disorders that interfered with sleep

Treatment and study plan

Xylometazoline

Drug

xylometazoline (0.1 % solution, 3 drops, 0.15 mg) in each nostril

Other names: Otrivin

Primary outcomes

sleep related breathing disturbances sleep efficiency daytime sleepiness

Time frame: at end of one week treatment

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Does Nasal Decongestion Improve Obstructive Sleep Apnea ?

Important dates

Study start: 2004
Primary completion: 2005
Study completion: 2005
First posted: Mar 7, 2008
Registry last updated: Dec 23, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed