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NCT Number: NCT07468266

Nasal Airflow in Post-operative Patients

The goal of this investigation is to examine the effect of nasal airflow in invasively ventilated adult patients following planned surgery. The main questions it aims to answer are:

* Does the investigational device produce an effect measured by EEG? * Are there differences in effect with modified airflow states?

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Key information

Conditions

Invasive Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Critical Care Medicine, Auckland City Hospital

Auckland, New Zealand

Location contact

Christopher Hands

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults >18 years of age
  • Receiving sedation via propofol and fentanyl
  • Undergoing surgical procedure with planned post-operative invasive ventilation

Exclusion criteria

  • Pre-existing neurological injury or condition

Treatment and study plan

TUI-1

Device

Provision of airflow to the nasal cavity by F&P Tui at baseline rate

TUI-2

Device

Provision of airflow to the nasal cavity by F&P Tui at modified rate

Primary outcomes

  1. Power spectral density of EEG

    Time frame: Before and 10 minutes after initiation of nasal airflow

    Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands

Secondary outcomes

  1. Power spectral density of EEG between interventions

    Time frame: 10 minutes after initiation of nasal airflow

    Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands and compared between TUI-1 and TUI-2

  2. Coherence

    Time frame: Before and 10 minutes after initiation of nasal airflow

    Inter-regional EEG coherence will be quantified as a measure of functional connectivity

Study contacts

Contact information is provided by the study sponsor or research team.

Kelly Gradon

CONTACT

[email protected]

09 574 0100

Sponsors and collaborators

Lead sponsor

Fisher and Paykel Healthcare

Industry

Registry information

Official study title

Impacts of F&P Tui on Cortical Activity in Invasively Ventilated Post-operative Patients

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 12, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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