NCT Number: NCT02002559
Narrow Band Imaging (NBI) Against Lugol for Squamous Esophageal Cancer
This study aimed to compare Narrow Band Imaging (NBI) against Lugol chromoendoscopy for diagnosis of early esophageal cancers among high risk patients.
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Conditions
Age range
18 year–80 year
Sex eligibility
All sexes
Study type
Observational
About this study
The investigators recruited consecutive patients with head and neck cancers, history of squamous esophageal cancers treated by chemoradiotherapy or endoscopic resection. Endoscopic surveillance first started with NBI for detection and characterization of early esophageal cancers through observation of abnormal intrapapillary capillary loops (IPCL). Superficial esophageal neoplasia were diagnosed by IPCL Type IV, V1,V2 and Vn. Lugol chromoendoscopy would be performed subsequently and suspicious neoplasia were classified as understain or unstain lesions. The diagnostic accuracy, sensitivity and specificity of NBI were compared to Lugol chromoendoscopy with histology serving as a gold standard.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients with Head and Neck Cancer
- Patients with esophageal cancer treated by chemoradiotherapy and in remission for 2 years
- Patients with esophageal cancer treated by endoscopic resection
- Age 18 to 80
Exclusion criteria
- Allergy to Lugol iodine
- Pregnancy
- Previous esophagectomy
Treatment and study plan
Primary outcomes
-
Diagnostic accuracy of superficial esophageal neoplasia
Time frame: 1 month
Sponsors and collaborators
Lead sponsor
Chinese University of Hong Kong
Other
Registry information
Official study title
Endoscopic Surveillance Comparing Narrow Band Imaging (NBI) Against Lugol Chromoendoscopy for Detection of Synchronous Superficial Squamous Esophageal Neoplasia Among High Risk Patients
Important dates
- Study start
- 2006
- Primary completion
- 2010
- Study completion
- 2010
- First posted
- Dec 6, 2013
- Registry last updated
- Jul 23, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.