Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

Primary Objectives

• To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care

Secondary Objectives

• To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
• To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
• To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.

Eligibility Criteria

• Scheduled to undergo ultrasound guided nsPFA as standard of care
• Age 18 to 80 years.
• Capable of providing independent consent.
• Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

• Benign FNA X 2 or
• Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
• Benign FNA X 1 and radiographic/laboratory evidence of functional nature
• Nodule measuring >2cm in greatest dimension
• Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
• No abnormal cervical lymph nodes during screening visit .

Exclusion criteria

• Age <18
• Patients considered unsuitable for nsPFA by the treating physician