NanoKnife Low Energy Direct Current (LEDC) System in Subjects With Locally Advanced Unresectable Pancreatic Cancer

Inclusion criteria

• male or female
• >/= 18 years of age
• meets criteria for locally advanced unresectable pancreatic adenocarcinoma, as radiographically proven pancreatic cancer as determined by a surgical oncologist via pancreatic CT or who were initially thought to be resectable; however at the time of surgery were upstaged to unresectability, via direct visualization
• tumor size must be < 4 cm and must be measurable
• must have an INR <1.5
• must be unresponsive to chemotherapy as demonstrated with either CT or MR imaging and not have taken any chemotherapy agents within 14 days of treatment with the NanoKnife LEDC System
• are willing and able to comply with the protocol requirements
• are able to comprehend and willing to sign an Informed Consent Form (ICF)

Exclusion criteria

• a baseline creatinine reported as > 2.0 mg/dL
• have any reported baseline lab values with a grade 3 or 4 toxicity as defined by the CTCAE Version 3.0
• inability to stop antiplatelet and Coumadin therapy for 7 days prior to and 7 days post treatment with the NanoKnife System
• known history of contrast allergy that cannot be medically managed
• known hypersensitivity to the metal in the electrodes (stainless steel 304L) that cannot be medically managed
• unable to be treated with a muscle blockade agent (e.g. pancuronium bromide, atracurium, cisatracurium, etc)
• women who are pregnant or currently breast feeding
• women of childbearing potential who are not utilizing an acceptable method of contraception
• have taken an investigational agent within 30 days of visit 1
• have implanted cardiac pacemakers or defibrillators
• have implanted electronic devices or implants with metal parts in the immediate vicinity of a lesion
• have a history of epilepsy or cardiac arrhythmia (atrial or ventricular fibrillation)
• have a recent history of myocardial infarction (within the past 2 months)
• have Q-T intervals greater than 550 ms unless treated with an Accysync Model 72 synchronization system controlling the NanoKnife system's output pulses.