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NCT Number: NCT07693595

Nailfold Capillaroscopic Changes in Psoriasis

The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity. The study will also explore differences in capillaroscopic findings across different clinical types of psoriasis and skin phototypes (Fitzpatrick classification). The study will include patients diagnosed with psoriasis attending dermatology outpatient clinics. Participants will undergo clinical assessment and nailfold capillaroscopy to detect microvascular changes.

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Key information

Conditions

Psoriasis Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Al-Hussein University Hospital & Sayed Galal University Hospital

Cairo, Cairo Governorate, Egypt

Location status: Recruiting

Location contact

Ahmed H Nouh, Asst Prof Derm & Venereolog

CONTACT

[email protected]

+201062034079

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients clinically diagnosed with psoriasis.

Exclusion criteria

  • Patients with connective tissue diseases (e.g., systemic sclerosis, SLE)
  • Diabetes mellitus or peripheral vascular disease
  • Current smokers
  • Pregnant or lactating women
  • Recent use of vasodilators or beta-blockers
  • Manual workers exposed to vibrating tools

Treatment and study plan

Nailfold Capillaroscopy

Other

Participants will undergo nailfold capillaroscopy using a USB digital capillaroscope to assess microvascular changes in psoriatic patients. Clinical assessment including PASI score and evaluation of nail involvement will also be performed.

Other names: Dermoscopy (if used for nails)

Primary outcomes

  1. Nailfold capillaroscopic abnormalities in psoriasis patients

    Time frame: Baseline

    Detection and description of nailfold capillaroscopic (NFC) abnormalities in patients with psoriasis.

Secondary outcomes

  1. Variation of nailfold capillaroscopic findings among different clinical types of psoriasis and correlation with disease severity (PASI score).

    Time frame: Baseline

    Correlation between PASI score and presence of NFC changes.

    • Comparison of nailfold capillaroscopic findings in different types of psoriasis

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed H Nouh, Asst Prof Derm & Venereol

CONTACT

[email protected]

+201062034079

Hadil J Albarrawi

CONTACT

[email protected]

+201096205545

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Nailfold Capillaroscopic Changes in Psoriasis and Its Correlation With Disease Severity

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 9, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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