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Completed

NCT Number: NCT06070935

Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

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Key information

Conditions

Uveitis Eye Diseases Uveal Diseases

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Maha Abdelrahman

Asyut, 71515, Egypt

About this study

The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls.

The NFC parameters are:

capillary density (number of capillaries per mm), dilated capillaries (apex of >20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with uveitis < 18 years old

Exclusion criteria

  • infectious uveitis
  • age > 18 years old

Treatment and study plan

Primary outcomes

  1. capillary density by nailfold capillaroscopy

    Time frame: 6 months

    (number of capillaries per mm)

  2. detection of number of dilated capillaries by nailfold capillaroscopy

    Time frame: 6 months

    number of dilated capillaries (apex of >20µm)

  3. detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology

    Time frame: 6 months

    detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries

Secondary outcomes

  1. correlation of nailfold findings with uveitis activity

    Time frame: 6 months

    correlation of capillary abnormalities detected with active uveitis.

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 6, 2023
Registry last updated
Aug 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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