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NCT Number: NCT05158751

Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry

To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.

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Key information

Conditions

Myocarditis Arrhythmias, Cardiac Cardiac Complexes, Premature Cardiac Conduction System Disease Cardiomyopathies Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Premature Ventricular Contractions Tachycardia Tachycardia, Ventricular Ventricular Premature Complexes Ventricular Tachycardia (VT)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kansas City Heart Rhythm Institute

Overland Park, Kansas, 66211, United States

Location contact

Donita Atkins

CONTACT

[email protected]

816-651-1969

About this study

Hypothesized that occult inflammation is clinically under-recognized in patients with symptomatic PVCs with and without Left ventricular (LV) dysfunction and can be a potential link between the 2 conditions. Aimed to evaluate the incidence of underlying inflammation using the Positron emission tomography (PET) scan in patients presenting with symptomatic PVCs enrolled retrospectively in the MAVERIC registry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients > 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
  • Non-sustained VT was defined as ≥3 more consecutive beats lasting <30 seconds

Exclusion criteria

  • History of myocardial infarction,
  • Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
  • History of revascularization,
  • Significant symptomatic atrial arrhythmias associated with LV dysfunction,
  • Severe valvular disease,
  • Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
  • History of cardiac arrest,
  • History of channelopathies or inherited arrhythmias.

Treatment and study plan

Primary outcomes

  1. Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF

    Time frame: Retrospective Collection between dates January 2014-January 2023

    To identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF through laboratory testing, FDG-PET(18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose - positron emission tomography) scan, Cardiac Magnetic Resonance imaging and/or Endomyocardial biopsy.

Secondary outcomes

  1. Ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes

    Time frame: Retrospective Collection between dates January 2014-January 2023

    To ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes in virus negative and FDG-PET positive patients with non-ischemic cardiomyopathy, myocardial inflammation and PVCs.

Other outcomes

  1. Evaluate whether IST + catheter ablation results in optimal clinical response

    Time frame: Retrospective Collection between dates January 2014-January 2023

    To evaluate whether IST + catheter ablation results in optimal clinical response in virus negative and FDG-PET positive patients with PVCs with or without reduced LVEF

Study contacts

Contact information is provided by the study sponsor or research team.

Donita Atkins

CONTACT

[email protected]

816-651-1969

Sponsors and collaborators

Lead sponsor

Kansas City Heart Rhythm Research Foundation

Other

Collaborators

  • Kansas City Heart Rhythm Institute

Registry information

Acronym: MAVERIC

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Dec 15, 2021
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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