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Completed

NCT Number: NCT05107102

Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With STEMI

The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.

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Key information

Conditions

ST-Segment Elevated Myocardial Infarction Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Ventricular Remodeling

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200125, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;
  • Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.

Exclusion criteria

  • significant valvular disease;
  • cardiomyopathy; l
  • left bundle branch block;
  • atrial fibrillation;
  • previous myocardial infarction (MI);
  • history of cardiac surgery;
  • pacemaker implantation.

Treatment and study plan

Primary outcomes

  1. Delta-work efficiency by echocardiography

    Time frame: 24-72 hours after PCI

    A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.

Secondary outcomes

  1. Global work index by echocardiography

    Time frame: 24-72 hours, 3-month after PCI

    Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening.

  2. Global constructive work by echocardiography

    Time frame: 24-72 hours, 3-month after PCI

    Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation.

  3. Global work efficiency by echocardiography

    Time frame: 24-72 hours, 3-month after PCI

    Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.

  4. Work index-LAD

    Time frame: 24-72 hours, 3-month after PCI

    Work index in left anterior descending(LAD) territory.

  5. Constructive work-LAD

    Time frame: 24-72 hours, 3-month after PCI

    constructive work in left anterior descending(LAD) territory.

  6. Work efficiency-LAD

    Time frame: 24-72 hours, 3-month after PCI

    Work efficiency in left anterior descending(LAD) territory.

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Value of Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction Treated by Primary Percutaneous Intervention

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Nov 4, 2021
Registry last updated
Nov 4, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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