Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

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Key information

Conditions

Myocardial Injury Behavior Motor Activity

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Norwegian University of Science and Technology, Medical Faculty

Trondheim, Sør-Trondelag, 7489, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing coronary heart surgery and heart transplantation

Exclusion criteria

myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)

Treatment and study plan

Exercise Training

Behavioral

exercise training

Remote ischemic preconditioning

Procedure

remote ischemic preconditioning

Primary outcomes

Mitochondrial respiration

Time frame: 1 hour

Oxygraph (Strathkelvin)

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

St. Olavs Hospital

Registry information

Official study title

Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Acronym: TRIMRIPC

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Mar 3, 2011
Registry last updated: Aug 20, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed