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OpenTrials
Completed

NCT Number: NCT01897350

Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial

Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.

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Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bristol Heart Institute

Bristol, Avon, BS2 8HW, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • STEMI
  • providing written informed consent

Exclusion criteria

  • contraindication to CMR,
  • atrial fibrillation,
  • claustrophobia,
  • eGFR < 30

Treatment and study plan

Cardiac Magnetic Resonance Imaging

Other

Primary outcomes

  1. The mass of myocardial oedema measured by CMR

    Time frame: Day 2 following STEMI

Secondary outcomes

  1. Extra cellular volume

    Time frame: Day 2 following STEMI

Sponsors and collaborators

Lead sponsor

Elisa McAlindon

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
First posted
Jul 12, 2013
Registry last updated
Oct 21, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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