Skip to main content
OpenTrials
Completed

NCT Number: NCT04358952

Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients

The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cardiomyopathies COVID-19 Cardiovascular Diseases Coronaviridae Infections Coronavirus Infections Heart Diseases Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UHToulouse

Toulouse, 31059, France

About this study

A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex.

Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Exclusion criteria

  • Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.

Treatment and study plan

Global Longitudinal Strain

Diagnostic Test

Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction

Primary outcomes

  1. Left ventricular function

    Time frame: Day 0

    Left ventricular function evaluated by global longitudinal strain

  2. Left ventricular function

    Time frame: Day 3

    Left ventricular function evaluated by global longitudinal strain

  3. Left ventricular function

    Time frame: Day 7

    Left ventricular function evaluated by global longitudinal strain

Secondary outcomes

  1. inflammatory biological parameters

    Time frame: Day 0

    Cytokine rate

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Imaging Cardiac Phenotype of SARS-Cov-2 (Covid19) Infected Patients

Acronym: COCARDE

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Apr 24, 2020
Registry last updated
Jun 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.