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OpenTrials
Completed

NCT Number: NCT01805193

Myocardial Blood Flow by 15O Water PET

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

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Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical Research Imaging Centre

Edinburgh, Scotland, United Kingdom

About this study

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • suspected coronary artery disease

Exclusion criteria

  • inability or unwillingness to undergo CT or PET imaging
  • renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)
  • hepatic failure
  • allergy to iodinated contrast
  • pregnancy
  • contraindication to adenosine
  • inability to give informed consent
  • atrial fibrillation with a fast ventricular rate (>70 beats per minute)

Treatment and study plan

Computed tomography myocardial perfusion imaging

Other

Oxygen 15 labelled water positron emission tomography

Other

Primary outcomes

  1. Myocardial blood flow

    Time frame: 1 month

    Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary outcomes

  1. Fractional flow reserve

    Time frame: 1 month

    Fractional flow reserve measured during invasive coronary angiography

  2. Myocardial perfusion

    Time frame: 1 month

    Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Registry information

Official study title

Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

Important dates

Study start
2012
Primary completion
2014
Study completion
2019
First posted
Mar 6, 2013
Registry last updated
Feb 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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