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OpenTrials
Completed

NCT Number: NCT00213629

myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.

Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies.

Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.

Completed

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Key information

Conditions

Polymyositis Connective Tissue Diseases Dermatomyositis Muscular Diseases Musculoskeletal Diseases Myositis Nervous System Diseases Neuromuscular Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–76 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Rouen

Rouen, Seine Maritime, 76000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • indication of muscle biopsy for diagnostic purpose
  • written informed consent

Exclusion criteria

  • vasculitis
  • coagulation disorder, impossibility to perform muscle biopsy

Treatment and study plan

transcriptome analysis

Other

transcriptome analysis from muscle biopsy

T cell repertoire analysis

Other

blood T cell repertoire analysis

Primary outcomes

  1. transcriptome

    Time frame: at inclusion

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Collaborators

  • Association Française contre les Myopathies (AFM), Paris

Registry information

Official study title

Transcriptome Analysis Through a Dedicated Macro-array and TcLandscape Repertoire Analysis for Diagnosis of Myositis.

Acronym: MYOARRAY

Important dates

Study start
2004
Primary completion
2010
Study completion
2010
First posted
Sep 21, 2005
Registry last updated
Feb 16, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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