MYeloma Resistance And Clonal Evolution

The MYRACLE cohort study aims at including all patients (>18 years old) who are diagnosed with MM in any stage of the disease and treated in specialized oncology centers in 2 public hospitals in Northwestern France. Any such patient providing a signed informed consent is included. All subjects are followed up until refusal to participate in the study, emigration or death. The MYRACLE follow-up is continuous and collects data on socio-economic status, medical status, MM therapies and associated events (resistance, side effects). Participants also complete standardized quality of life (QOL) questionnaires. In addition, participants are asked to donate blood samples that will support ex vivo analysis of expression and functional assays required to uncover predictive biomarkers and companion diagnostics. If diagnostic biopsies are performed during the course of the disease, extracted biological samples are kept in a dedicated biobank.

Inclusion criteria

• Patient consulting due to the discovery or recurrence of MM according to international diagnostic criteria (IMWG 2014)
• Patient having consented to participate in the study and his/her biocollection
• Patient affiliated to or benefiting from a social security scheme or similar

Exclusion criteria

• Minors
• Major under guardianship or curatorship
• Protected persons.
• Pregnant or breast-feeding women
• Persons benefiting from the AME