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Recruiting

NCT Number: NCT05968417

Myeloma Novel Drug Discovery Ver 1.2

Myeloma is a bone marrow cancer with over 5000 patients diagnosed in the UK each year. Researchers are committed to improving understanding of myeloma and developing more effective treatments with fewer side effects in order to improve patient outcomes. In order to do this, researchers are collecting samples of blood and bone marrow to test the activity of potential new treatments in the laboratory and to understand what may be the cause of some treatments not working.

Recruiting

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Key information

Conditions

Multiple Myeloma Blood Protein Disorders Cardiovascular Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Immune System Diseases Immunoproliferative Disorders Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Neoplasms, Plasma Cell Paraproteinemias Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Royal Marsden NHS Foundation Trust

Sutton, SM25PT, United Kingdom

Location status: Recruiting

Location contact

Charlotte Pawlyn

PRINCIPAL_INVESTIGATOR

Chloe Burrows

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants who have a diagnosis, or suspected diagnosis, of myeloma or related plasma cell disorder
  • Participants who are undergoing a peripheral blood or bone marrow aspirate sampling for diagnostic, staging or follow-up purposes, before, whilst or after receiving anti-myeloma treatment
  • Participants aged 18 years of age or above
  • Participants willing to consent to an additional sample being taken at the time of their peripheral blood or bone marrow aspirate sampling

Exclusion criteria

  • Participants unable to provide consent
  • Participants with known active infectious diseases (e.g. HIV, Hepatitis B/C, COVID) that pose a risk to the use of the sample in the laboratory

Treatment and study plan

Observational study - sample collection only.

Other

No intervention - blood and/or bone marrow sample collection only

Primary outcomes

  1. Cell viability

    Time frame: 12 months

    Myeloma cell viability when incubated with standard of care and novel compounds.

Study contacts

Contact information is provided by the study sponsor or research team.

Disco Team

CONTACT

[email protected]

020 3186 5275

Sponsors and collaborators

Lead sponsor

Institute of Cancer Research, United Kingdom

Other

Collaborators

  • Royal Marsden NHS Foundation Trust

Registry information

Official study title

Investigation of the Activity of Novel Compounds for the Treatment of Myeloma and Mechanisms of Drug Resistance to Current Therapies

Acronym: DISCO

Important dates

Study start
2020
Primary completion
2033
Study completion
2035
First posted
Aug 1, 2023
Registry last updated
Aug 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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