Myeloid Suppressors in Inflammation

Myeloid-derived suppressor cells (MDSC) have been studied for their ability to suppress T cell responses in vivo and in vitro. As a result, MDSC can regulate cellular responses to chronic inflammatory conditions such as cancer, leading to the induction of tolerance and, ultimately, tumor escape from immune surveillance.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

USF Asthma, Allergy and Immunology CRU

Tampa, Florida, 33613, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion

Ages eligible for study: 18 to 60 years
Genders eligible for study: male and female
Signed and dated written informed consent is obtained prior to study blood draw.
Subjects being actively treated for chronic moderate to severe asthma based on National Heart Lung and Blood Institute guidelines (figure 1). Subjects must carry the diagnosis of asthma (made by a physician) for a minimum of six months.
Subjects within the first seven days of an acute asthma exacerbation, as determined by the referring physician.
Able to give informed consent.

Exclusion criteria

Use of systemic corticosteroids within the previous two weeks.
Pregnant and/or lactating females.
Current tobacco use.
Severe psychiatric illness.
Current illicit substance abuse or dependence and/or abuse of alcohol.
Current use of anti-microbial medications.
Primary or secondary immunodeficiency.
Any clinically significant uncontrolled medical condition that would put the patient's safety at risk.

Treatment and study plan

Primary outcomes

To identify and characterize specific cell types (human dendritic cells, myeloid-derived suppressor cells and T lymphocytes) that are present in acute and chronic asthma.

Time frame: one year from start of study

Sponsors and collaborators

Lead sponsor

University of South Florida

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Oct 19, 2010
Registry last updated: Jun 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed