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Completed

NCT Number: NCT04084639

Mycoprotein Consumption and Glucose Absorption

Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.

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Key information

Conditions

Healthy

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female
  • 18-35 years of age
  • Consumption of sufficient amounts of carbohydrate in the diet
  • Body mass index between 18.5 and 30

Exclusion criteria

  • Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes), or other form of abnormal glucose metabolism (as this will affect outcome of the study).
  • Any diagnosed cardiovascular disease
  • Insufficient consumption of carbohydrate in the diet
  • A personal or family history of epilepsy, seizures or schizophrenia
  • Known pre-existing liver disease/condition
  • Allergy or intolerance to milk

Treatment and study plan

Mycoprotein Ingestion

Dietary Supplement

Ingestion of various doses of mycoprotein compared to placebo control

Primary outcomes

  1. Glucose absorption

    Time frame: 6 hours following ingestion of drink

    How glucose is absorbed following the ingestion of a mycoprotein drink compared to a placebo control measured using the infusion of stable isotopes

Secondary outcomes

  1. Incretin Hormones

    Time frame: 6 hours following ingestion of drink

    Measurement of glucagon-like peptide-1(GLP-1) and gastric inhibitory polypeptide (GIP) in response to mycoprotein ingestion compared to placebo control

  2. Insulinaemic Response

    Time frame: 6 hours following ingestion of drink

    Measurement of insulin response following ingestion of drinks

  3. Production of Short-Chain Fatty Acids

    Time frame: 6 hours following ingestion of drink

    Measurement of plasma acetate production in response to mycoprotein ingestion

  4. Glucose Kinetics

    Time frame: 6 hours following ingestion of drink

    Calculations using plasma deuterated glucose enrichment to determine rate of appearance of endogenous glucose, rate of disappearance of glucose and rate of appearance of exogenous glucose

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • Quorn

Registry information

Official study title

To Determine the Effects of Mycoprotein Consumption on Glucose Absorption in Healthy Participants

Acronym: MEGA

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Sep 10, 2019
Registry last updated
Nov 8, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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