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OpenTrials
Completed

NCT Number: NCT04894747

Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.

Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30
  • Resistance trained

Exclusion criteria

  • Any metabolic impairment
  • Smoking
  • Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
  • A personal family history of epilepsy, seizures or schizophrenia.
  • Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
  • Any motor disorder.

Treatment and study plan

Bolus ingestion of protein

Dietary Supplement

Ingestion of 25g of protein

Other names: Protein ingestion

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 8.5 hours

    The rate of synthesis of new muscle protein (Fractional synthetic rate %/h)

Secondary outcomes

  1. Plasma amino acid kinetics

    Time frame: 8.5 hours

    The appearance of amino acids from the protein drink in the circulation.

  2. Serum insulin concentrations

    Time frame: 8.5 hours

    Basal and postprandial concentrations of serum insulin

  3. Translocation of mTOR via immunohistochemistry

    Time frame: 8.5 hours

    Locality of mTOR within the muscle cell

  4. mTOR phosphorylation via ATP kinase assay

    Time frame: 8.5 hours

    The amount of mTOR that has been activated in the muscle cell

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • Quorn

Registry information

Official study title

Comparing Postprandial Muscle Protein Synthesis Rates Following the Consumption of Mycoprotein, Pea Protein and a Mycoprotein/Pea Protein Blend in Resistance Trained Individuals

Acronym: BPM

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
May 20, 2021
Registry last updated
Mar 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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