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OpenTrials
Completed

NCT Number: NCT04084652

Mycoprotein and Muscle Protein Synthetic Response

Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients).

Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).

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Key information

Conditions

Anabolic Response to Mycoprotein and Micronutrient Ingeston

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30.
  • Resistance trained

Exclusion criteria

  • Any metabolic impairments.
  • Cardio/pulmonary diseases.
  • Chronic use of over the counter pharmaceuticals
  • A personal or family history of epilepsy, seizures or schizophrenia.
  • Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Treatment and study plan

Mycoprotein Ingestion

Dietary Supplement

The ingestion of mycoprotein

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 7.5 hours

    The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)

Secondary outcomes

  1. Plasma Amino Acid Kinetics

    Time frame: 7.5 hours

    The rate of appearance of amino acids ingested in the drink

  2. Blood Glucose

    Time frame: 7.5 hours

    The levels of glucose in the blood

  3. Serum Insulin

    Time frame: 7.5 hours

    The levels of insulin in blood serum

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • Quorn

Registry information

Official study title

Comparing the Muscle Protein Synthetic Response to Ingestion of Mycoprotein vs Protein Isolated From Mycoprotein

Acronym: PIMP

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Sep 10, 2019
Registry last updated
May 27, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.