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NCT Number: NCT07653360

Music Therapy for Oral Mucositis Pain in Pediatric Patients

This mixed-methods pilot study will examine the effect of music therapy on oral mucositis pain in pediatric oncology patients. Oral mucositis, characterized by painful ulcerative lesions in the mouth, is a common side effect of high-dose chemotherapy and hematopoietic stem cell or bone marrow transplantation. Despite its high prevalence and impact on quality of life, effective pain management strategies for pediatric oral mucositis remain limited and often rely heavily on medications that may cause significant side effects or provide insufficient relief. Music therapy may offer a promising non-pharmacologic adjunct for reducing pain, yet no studies to date have specifically evaluated its use for oral mucositis pain in pediatric patients.

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Key information

Conditions

Oral Mucosa Discomfort Mouth Diseases Mucositis Oral Neoplasms Pediatric Cancer Stomatitis Stomatognathic Diseases

Age range

6 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Phase 1:

Aim 1a: Explore the experiences of oral mucositis pain in pediatric patients.

Aim 1b: Explore how pediatric patients perceive the involvement of music therapy during oral mucositis pain.

Phase 1 of the study involves semi-structured interviews with parent-child dyads about the child's experiences with oral mucositis and their perceptions of music therapy while experiencing oral mucositis pain. Information obtained in Phase 1 will direct the development and design of the Interventional Phase (Phase 2) not yet enrolling.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Phase 1

  • Child ages 6-18 years old
  • Child has received music therapy and experienced oral mucositis
  • Parent/guardian 18 years and older
  • Able to communicate in English

Exclusion criteria

Phase 1

  • Diagnosis of a developmental disorder that would prevent engagement in the active music-making or passive music-listening intervention or completion of study measures.
  • Significant pre-existing hearing loss or impairment that would interfere with participation in the interventions.

Treatment and study plan

semi-structured interviews

Other

Participants will be interviewed online via Zoom

Primary outcomes

  1. Identify patterns in previous experience with music therapy

    Time frame: 1 day

    Semi-structured interviews will be audio/video-recorded and transcribed using Zoom's built-in transcription function. Finalized transcripts will be analyzed using reflexive thematic analysis, a qualitative method for identifying and interpreting patterns within the data.

Study contacts

Contact information is provided by the study sponsor or research team.

Jonathan Tang, MT-BC, PhD

CONTACT

[email protected]

(415) 353-3327

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Collaborators

  • Perloff Family Foundation

Registry information

Official study title

Effect of Music Therapy on Oral Mucositis Pain in Pediatric Patients

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 17, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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