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OpenTrials
Enrolling by Invitation

NCT Number: NCT07393503

Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries

In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain:

1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions 2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin)

The investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.

Enrolling by Invitation

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Key information

Conditions

Musculoskeletal Pain Muscular Diseases Musculoskeletal Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

UBMD Orthopaedics and Sports Medicine (716 Health)

Buffalo, New York, 14221, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults 18+
  • Able to answer survey questions in English
  • MSK pain > 3 on the VAS scale in any body part
  • Invited to participate by and enrolling clinician

Exclusion criteria

  • > 2 weeks from pain onset
  • Fractures
  • Active infections
  • Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and/or Acetaminophen)
  • Currently taking anti-platelet agents (aspirin </= 100/mg a day, clopidogrel, etc.)
  • Chronic Kidney Disease Stage 3 or worse
  • Uncontrolled diabetes (A1C above 9)
  • Currently taking oral anti-coagulants
  • History of bleeding ulcer
  • Cirrhosis
  • Taking daily prednisone
  • Chronic pain syndrome
  • Chronic pain medication (gabapentin, Lyrica, narcotics, etc.)
  • Pregnant Patients
  • Worker's Compensation Patients

Treatment and study plan

Methylprednisolone 4Mg Tab

Drug

Participants follow standard 6- day taper dosing schedule.

Other names: Medrol

Acetaminophen 500Mg Tab

Drug

Participants follow a 6- day taper dosing schedule.

Other names: Tylenol

Ibuprofen 200Mg Oral Tablet

Drug

Participants follow a 6- day taper dosing schedule.

Other names: Motrin

Primary outcomes

  1. Change in Pain

    Time frame: 1 week, 1 month

    Pain as self-reported by the patient, following pain medication treatment for an acute musculoskeletal (MSK) injury as measured with the Visual Analog Scale (VAS) where 0 is no pain at all and 10 is the worst pain imaginable. Lower scores indicate less pain.

Secondary outcomes

  1. Change in Function

    Time frame: 1 week, 1 month

    Function as self-reported by the patient following pain medication treatment for an acute musculoskeletal (MSK) injury as measured with the musculoskeletal health questionnaire (MSK-HQ) scale which sums 14 health domains on a 5-point scale from 4 being not at all and 0 to very severe. Higher scores indicate better overall MSK health.

Sponsors and collaborators

Lead sponsor

State University of New York at Buffalo

Other

Registry information

Acronym: MOTION

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Feb 6, 2026
Registry last updated
Feb 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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