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Completed

NCT Number: NCT05108181

Muscle Typology and Strength Training Adaptations

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.

Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

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Key information

Conditions

Muscle Fiber Type Behavior Exercise Motor Activity Training Frequency

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, 9000, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fast or slow muscle typology
  • 18 - 45 years old
  • no strength training experience

Exclusion criteria

  • Vegan/vegeterian diet
  • Supplement intake
  • chronic diseases
  • Hypertension,
  • Smoking
  • Medication use
  • Coagulation disorder, infectious diseases

Treatment and study plan

Muscle typology + exercise training

Other

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Muscle typology + training frequency

Other

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Primary outcomes

  1. Change from baseline muscle volume at 9 weeks

    Time frame: Pre and post the 9 weeks training period

    Muscle volume of the legs and the upper arms - MRI

  2. Change from baseline dynamic muscle strength at 3 weeks

    Time frame: Pre, mid and post 9 weeks training period

    Upper legs and upper arms - strength training devices

  3. Change from baseline dynamic muscle strength at 6 weeks

    Time frame: Pre, mid and post 9 weeks training period

    Upper legs and upper arms - strength training devices

  4. Change from baseline dynamic muscle strength at 9 weeks

    Time frame: Pre, mid and post 9 weeks training period

    Upper legs and upper arms - strength training devices

  5. Change from baseline isometric muscle strength at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Upper legs and upper arms - Biodex

  6. Change in muscle fiber type specific hypertrophy at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Legs - Biopsy (vastus lateralis)

Secondary outcomes

  1. Change of baseline antropometry at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Height, weight, skinfolds

  2. Change of baseline skeletal muscle protein content at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Histochemistry and protein content of markers of relevance for skeletal muscle function

  3. Change of baseline histochemistry at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Histochemistry of markers of relevance for skeletal muscle function

  4. Change from basline fatigue feeling over 9 weeks training period

    Time frame: Assessed every training during the 9 weeks training period

    Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training

  5. Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks

    Time frame: Pre and post 9 weeks training period

    Fasted blood samples

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Registry information

Official study title

Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations

Acronym: MT-ST

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Nov 4, 2021
Registry last updated
Apr 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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