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Completed

NCT Number: NCT02040363

Muscle Training Induced Angiogenesis in COPD

COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation.

Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).

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Key information

Conditions

Peripheral Muscle Dysfunction COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–78 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of clinical Physiology - University Hospital

Montpellier, 34295, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COPD patients :
  • FEV1<80%pred.
  • non exacerbation during the past 4 weeks
  • no oxygen therapy, -

Healthy subjects:

  • <150min/week of moderate-to-vigorous physical activity,
  • Voorrips score <9

Exclusion criteria

  • Unstable comorbidity
  • Long term oxygen therapy or ventilation
  • Rehabilitation program during the past 12 months
  • nutritional supplementation during the past 4 weeks
  • allopurinol or N-acetylcystein during the past 4 weeks
  • long corticosteroid treatment during the past 6 months
  • hyperreactivity to xylocain
  • anticoagulant or platelet aggregation inhibitors treatment
  • participation to an other research study-pregnancy or impossibility to provide informed consent, ...

Treatment and study plan

Muscular biopsy

Procedure

5-10 weeks sport training

Other

Primary outcomes

  1. Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps

    Time frame: 5 weeks

  2. Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps

    Time frame: 10 weeks

Secondary outcomes

  1. quadriceps endurance

    Time frame: 5 weeks

  2. quadriceps endurance

    Time frame: 10 weeks

  3. Pericyte coverage of skeletal muscles capillaries assessed by immunostaining of a muscle biopsy of the vastus lateralis of the quadriceps

    Time frame: 5 weeks

  4. Pericyte coverage of skeletal muscles capillaries assessed by immunostaining of a muscle biopsy of the vastus lateralis of the quadriceps

    Time frame: 10 weeks

  5. Effect of the serum of COPD patients and SHS on pericyte morphology and in vitro

    Time frame: 10 weeks

  6. Effect of the serum of COPD patients and SHS on pericyte/endothelial cells interactions in vitro

    Time frame: 10 weeks

  7. Effect of the serum of COPD patients and SHS on pericyte/endothelial cells interactions in vivo

    Time frame: 10 weeks

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Collaborators

  • 5 Santé
  • Institut National de la Santé Et de la Recherche Médicale, France
  • Université Montpellier

Registry information

Official study title

Impact of Exercise Training on Skeletal Muscle Capillary Maturation During Angiogenesis in COPD Patients

Acronym: COPDµvasc

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jan 20, 2014
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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