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OpenTrials
Completed

NCT Number: NCT03628508

Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis

Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.

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Key information

Conditions

Osteoarthritis, Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Queen Mary Hospital

Hong Kong

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 50-80
  • having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
  • having medial knee pain on most days of the month
  • having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking

Exclusion criteria

  • having lateral tibiofemoral compartment osteophytes greater than the medial side.
  • having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
  • having a systemic arthritic condition (e.g., rheumatoid arthritis)
  • having a knee joint replacement or high tibial osteotomy in the past
  • having any other muscular, joint or neurological condition influencing lower limb function
  • unable to walk unaided
  • having low back, hip, ankle or foot pain > 3 on numerical rating scale
  • having a body mass index (BMI) >36 kg/ m2

Treatment and study plan

Exercise

Other

Comprehensive exercise program including strengthening, stretching, gait modification etc.

Primary outcomes

  1. Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System

    Time frame: At baseline and one week after intervention

    External knee moment in the frontal plane during early stance phase of walking

Secondary outcomes

  1. Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score

    Time frame: At baseline and one week after intervention

    Pain intensity measured by the pain subscale of Knee injury and Osteoarthritis Outcome Score (KOOS). The minimum value is 0 and maximum value is 100. The higher scores mean a better outcome.

  2. Tibial Torsion as Assessed by X-ray Imaging

    Time frame: At baseline

    The angle between tibial and femur in the transverse plane

  3. Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography

    Time frame: At baseline and one week after intervention

    Young's modulus by ultrasound elastography

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Collaborators

  • Queen Mary Hospital, Hong Kong

Registry information

Official study title

External Tibia Torsion and Passive Muscle Stiffness of Quadriceps as Two Important Contributors of Joint Loading During Walking in People With Knee Osteoarthritis

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Aug 14, 2018
Registry last updated
Sep 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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