Skip to main content
OpenTrials
Completed

NCT Number: NCT03865095

Muscle Mass Loss in Critically Ill Patients.

The purpose of the study is to describe the change in muscle mass in critically ill patients. The study will examine rectus femoris cross sectional area with ultrasound and identify risk factors of this changes.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Muscle Loss Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Brno and Masaryk University Brno

Brno, 62500, Czechia

About this study

The study will commence following the Approval by The Ethics Research Committee. All patients admitted to our ICU from the 1st of March 2019 to the 31st of August 2019 will be enrolled after fulfilling the inclusion criteria and in the absence of any exclusion criteria. Informed consent will be requested. Ultrasound measurement of rectus femoris cross sectional area will be performed in first 24 hours after admission to ICU.

Study data will be entered in study form. The ultrasound measurement will be repeated on day 7 of hospitalisation.

Changes in rectus femoris cross sectional area and potential risk factors will be analysed. The length of ICU length of stay and 28-day mortality will be also monitored.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥18 years
  • mechanical ventilation expected for at least 48 hours

Exclusion criteria

  • Clinical Frailty Score above 7 prior admission
  • neuromuscular disease in previous medical history
  • amputated lower extremities
  • trauma of lower extremities involving tights
  • age under 18 years
  • inability to perform ultrasound examination
  • death or discharge prior completion of protocol
  • full verticalization prior completion of protocol

Treatment and study plan

Primary outcomes

  1. Muscle mass loss

    Time frame: 7 days

    Change in cross sectional area of rectus femoris muscle estimated by ultrasound

Secondary outcomes

  1. 28 day mortality

    Time frame: 28 days after enrolment

    mortality 28 days after enrolment

Sponsors and collaborators

Lead sponsor

Masaryk University

Other

Collaborators

  • Brno University Hospital

Registry information

Official study title

Muscle Mass Loss in Critically Ill and Its Risk Factors. A Prospective Observational Study.

Acronym: MUSIC

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 6, 2019
Registry last updated
Mar 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.